中国科学院大学温州研究院

智能多功能化生物材料的诊疗应用

主要研究方向：

1、智能化纳米材料递送基因药物；

2、多种药物自组装的自我递送；

3、肿瘤微环境响应的多级靶向递送体系；

4、联合药物递送

1.基因药物递送：

2.药物联合治疗：

3.诊疗一体化生物材料：

4. 药物自我递送：

沈建良

(简历)

钱宇娜

（简历）‍

Joy Wolfram

（简历）‍

秦涛

齐晓亮

李志鹏

申亮亮

赵圣哲

刘敏超

张航

陈梦宇

曾乾坤

沈建良 （博士）研究员，课题组长[close]

Tel： 0577-88017536

Email：shenjl@wibe.ac.cn

个人简介：

2010/09-2014/06 中山大学无机化学博士

2012/05-2014/05 美国休斯敦卫理公会研究所助理研究员

2014/06-2017/06 美国休斯敦卫理公会研究所博士后

2017/09-至今温州生物材料与工程研究所研究员

研究兴趣：1)智能化纳米材料递送基因药物；2)多种药物自组装的自我递送；3)肿瘤微环境响应的多级靶向递送体系；4)联合药物递送

　　研究主要集中于纳米材料、纳米技术在生物医学领域中的探究。通过合理的设计和优化具有智能多功能化的纳米/微米材料解决药物递送的瓶颈。主要应用于癌症的成像和治疗、以及其他疾病的诊疗一体化应用。利用纳米材料技术和多学科的交叉优势解决癌症和其他疾病医疗诊断等领域所面临的挑战和瓶颈。已申报美国专利1项，中国专利7项。在国际权威学术期刊已发表30多篇相关学术论文，如Chemical Society Reviews, Clinical Caner Research, ACS Nano, Nano Letters, Materials Today, Nature Biotechnology等。累积影响因子达320，被引达700余次。目前主持国家自然科学基金、生物材料与工程研究所重点专项和温州医科大学启动项目等450万经费。

已发表的代表性论文：

【1】 Shen J., Zhang W., Qi R.G., Mao Z.-W.,* Shen H.* Engineering Functional Inorganic-Organic Hybrid Nanoparticle Advances in siRNA Therapeutics. Chemical Society Reviews. 2018, 47, 1969-1995, IF: 40.182 
【2】 Mu C., Wu X., Zhou X., Wolfram J., Shen J., Zhang D., Mai J., Xia X., Holder A., Ferrari M., Liu X., Shen H.* Chemotherapy Sensitizes Therapy-Resistant Cells to Mild Hyperthermia by Suppressing Heat Shock Protein 27 Expression in Triple-Negative Breast Cancer. Clinical Cancer Research. 2018, doi: 10.1158/1078-0432.CCR-17-3872. IF: 10.199
【3】 Sun J.H., Zhang W., Zhang D.Y., Shen J., Tan C.P., Ji L.N., Mao Z.-W.* Multifunctional Mesoporous Silica Nanoparticles as Efficient Transporters of Doxorubicin and Chlorin e6 for Chemo-Photodynamic Combinatorial Cancer Therapy. Journal of Biomaterials Applications. 2018, 32, 1253-1264, IF: 2.082 
【4】 Wang F., Xia X., Yang C., Shen J., Mai J., Kim H.-C., Kirui D., Kang Y.A., Fleming J.B., Koay E.J., Mitra S., Ferrari M., Shen H.* SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy. Clinical Cance Research. 2018, 24, 3176-3185, IF: 10.199 
【5】 Mu C.F., Shen J., Liang J., Zheng H.S., Xiong Y., Wei Y.H., Li F.* Targeted Drug Delivery for Tumor Therapy Inside the Bone Marrow. Biomaterials. 2018, 155, 192-202, IF: 8.806 
【6】 Liu H., Mai J., Shen J., Wolfram J., Li Z., Zhang G., Xu R., Li Y., Mu C., Zu Y., Li X., Lokesh G.L., Thiviyanathan V., Volk D.E.,. Gorenstein D.G., Ferrari M2., Hu Z., Shen H.* A Novel DNA Aptamer for Dual Targeting of Polymorphonuclear Myeloid-derived Suppressor Cells and Tumor Cells. Theranostics. 2018, 8, 31-44, IF: 8.537 
【7】 Shen J., Liu H., Mu C., Wolfram J., Zhang W., Kim H.-C., Hu Z., Ji L.-N., Mao Z.-W.,* Shen H.* Multi-Step Encapsulation of Chemotherapy and Gene Silencing Agents in Functionalized Mesoporous Silica Nanoparticles. Nanoscale, 2017, 9, 5329-5341, IF: 7.367 
【8】 Shen J., Wolfram J., Ferrari M., Shen H.* Taking the Vehicle out of Drug Delivery Self-delivery Systems for Combination Therapy. Materials Today. 2017, 20, 95-97, IF: 24.537
【9】 Shen J., Kim H.-C., Wolfram J., Mu C., Zhang W., Liu H., Xie Y., Mai J., Zhang H., Li Z., Guevara M., Mao Z.-W., Shen H.* A Liposome Encapsulated Ruthenium Polypyridine Complex as a Theranostic Platform for Triple-Negative Breast Cancer. Nano Letters. 2017, 17, 2913-2920, IF: 12.712 
【10】 Shen J., Wu X., Lee Y., Wolfram J., Mao Z.-W., Ferrari M., Shen H.,* Porous Silicon Microparticles for Delivery of siRNA Therapeutics. Journal of Visualized Experiments. 2015, 52075, IF: 1.232
【11】 Shen J., Kim H.-C., Su H., Wang F., Wolfram J., Kirui D., Mai J., Mu C., Ji L.-N., Mao Z.-W.,* Shen H.* Cyclodextrin and Polyethylenimine Functionalized Mesoporous Silica Nanoparticles for Delivery of siRNA Cancer Therapeutics. Theranostics. 2014, 487-497, IF: 8.766 (ESI 1%) 
【12】 Shen J., Kim H.-C., Mu C., Genttile E., Mai J., Wolfram J., Ji L.-N., Ferrari M., Mao Z.-W.,* Shen H.* Multifunctional Gold Nanorods for siRNA Gene Silencing and Photothermal Therapy. Advanced Healthcare Materials. 2014, 1629-1637, IF: 5.110 
【13】 Shen J., Xu R., Mai J., Kim H.-C., Guo X., Qin G., Yang Y., Wolfram J., Mu C., Xia X., Gu J., Liu X., Mao Z.-W., Ferrari M., Shen H.* High Capacity Nanoporous Silicon Carrier for Systemic Delivery of Gene Silencing Therapeutics. ACS Nano 2013. 9867-9880, IF: 13.942 (ESI 1%) 
【14】 Liu H., Li Z., Mao Z.-W., Shen H., Qian Y.,* Shen J.* Biomedical Applications of Multifunctional Magnetic Nanoparticles Advance in Cancer Therapeutics. Acta Pharmaceutica Sinica B. 2018, (Invited Manuscript, Under Review) IF: 6.014 
【15】 Yang Z., Sun Z., Ren Y., Liu H., Mao Z.-W., Shen J.,* Nie S.* Nanomaterials Advance in Photothermal and Photodynamic Therapeutics. Nanoscale. 2018, (Under Review) IF: 7.367
【16】 Liu H., Mai J., Shen J., Wolfram J., Li Z., Zhang G., Xu R., Li Y., Mu C., Zu Y., Li X., Lokesh G.L., Thiviyanathan V., Volk D.E., Gorenstein D.G., Ferrari M., Hu Z., Shen H.* A Novel DNA Aptamer for Dual Targeting of Polymorphonuclear Myeloid-derived Suppressor Cells and Tumor Cells. Theranostics. 2018, 31-44, IF: 8.766 
【17】 Mu C.,* Shen J., Liang J., Zheng H.S., Xiong Y., Wei Y.H., Li F.* Targeted Drug Delivery for Tumor Therapy Inside the Bone Marrow. Biomaterials. 2018, 155, 191-202, IF: 8.402
【18】 Deng B., Xia M., Qian J., Li R., Li L., Shen J., Xie Y.* Calcium Phosphate-Reinforced Reduction-Sensitive Hyaluronic Acid Micelles for Delivering Paclitaxel in Cancer Therapy. Molecular Pharmaceutics. 2017, 14, 1938-1949, IF: 4.440
【19】 Zhang W., Shen J., Su H., Mu G., Sun J.-H., Tan C.-P., Liang X.-J., Ji L.-N., Mao Z.-W.* Co-Delivery of Cisplatin Prodrug and Chlorin e6 by Mesoporous Silica Nanoparticles for Chemo-Photodynamic Combination Therapy to Combat Drug Resistance. ACS Applied Materials & Interfaces. 2016, 13332-13340, IF: 7.504
【20】 Mu C., Wu X., Ma H., Tao W., Zhang G., Xia X., Shen J., Mai J., Sun T., Sun X., Arlinghaus R.-B, Shen H.* Effective Concentration of a Multikinase Inhibitor within Bone Marrow Correlates with In Vitro Cell Killing in Therapy-Resistant Chronic Myeloid Leukemia. Molecular Cancer Therapeutics. 2016, 899-910, IF: 5.764
【21】 Xu R., Zhang G., Mai J., Deng X., Segura-Ibarra V., Wu S., Shen J., Liu H., Hu Z., Chen L., Huang Y., Koay E., Huang Y., Liu J., Ensor J.-E., Blanco E., Liu X., Ferrari M.,* Shen H.* An Injectable Nanoparticle Generator Enhances Delivery of Cancer Therapeutics. Nature Biotechnology. 2016, 414-418, IF: 41.667 (ESI 1%)
【22】 Wolfram J., Scott B., Boom K., Shen J., Borsoi C., Suri K., Grande R., Fresta M., Celia C., Zhao Y., Shen H.* Hesperetin Liposomes for Cancer Therapy. Current Drug Delivery. 2016, 711-719, IF: 2.516
【23】 Scott B., Shen J., Nizzero S., Boom K., Persano S., Mi Y., Liu X., Zhao Y., Blanco E., Shen H., Ferrari M.,* Wolfram J.* A Pyruvate Decarboxylase-Mediated Therapeutic Strategy for Mimicking Yeast Metabolism in Cancer Cells. Pharmacological Research. 2016, 413-421, IF: 4.480
【24】 Wolfram J.,* Zhu M., Yang Y., Shen J., Gentile E., Paolino D., Fresta M., Nie G., Chen C., Shen H., Ferrari M., Zhao Y. Safety of Nanoparticles in Medicine. Current Drug Targets. 2015, 1671-1681, IF: 3.236
【25】 Wolfram J., Yang Y., Shen J., Moten A., Chen C., Shen H., Ferrari M., Zhao Y.* The nano-plasma Interface: Implications of the Protein Corona. Colloids Surfaces B: Biointerfaces. 2014, 17-24, IF: 3.887
【26】 Wolfram J., Suri K., Yang Y., Shen J., Celia C., Fresta M., Zhao Y., Shen H., Ferrari M.* Shrinkage of Pegylated and Non-pegylated Liposomes in Serum. Colloids Surfaces B: Biointerfaces. 2014, 294-300, IF: 3.887
【27】 Yang Y., Shen J., Yu X., Qin G., Zhang M., Shen H., Mao Z.-W,* Ferrari M.* Identification of an Inhibitory Mechanism of Luteolin on the Insulin-like Growth Factor-1 Ligand-Receptor Interaction. Chembiochem. 2013, 929-933, IF: 2.847
【28】 Yang Y., Wolfram J., Shen J., Yuan J., Zhao Y., Fang X., Shen H., Ferrari M.* Live-cell Single-molecule Imaging Reveals Clathrin and Caveolae Dependent Docking of SMAD4 at the Cell Membrane. FEBS Letters. 2013, 3912-3920, IF: 3.632
【29】 Tan L.,* Liu J., Shen J., Liu X., Zeng L., Jin L. First Ruthenium(II) Polypyridyl Complex As a True Molecular “light switch” for Triplex RNA Structure: [Ru(phen)2(mdpz)]2+ Enhances the Stability of poly(U)•poly(A)*poly(U). Inorganic Chemistry. 2012, 4417-4419, IF: 4.857
【30】 Tan L.,* Shen J., Liu J., Zeng L., Jin L., Weng C. Spectral Characteristics, DNA-Binding and Cytotoxicity of Two Functional Ru(II) Mixed-ligand Complexes. Dalton Transactions. 2012, 4575-4587, IF: 4.029
【31】 Tan L.,* Shen J., Chen X., Liang X. In Vitro Study on DNA Binding of Ruthenium(II) Complexes with Polypyridyl Ligands. DNA and Cell Biology. 2009, 461-468, IF: 2.344
【32】 Tan L.,* Chen X., Shen J. Synthesis, Characterization, DNA-Binding, and DNA-Photocleavage Properties of Ru(II) Complexes. Australian Journal of Chemistry. 2009, 1646-1654, IF: 1.558
【33】 Huang X., Chen X., Shen J., Su G.* Synthesis, Characterization and DNA-binding Studies of Complexes [Co(phen)2(CPIA)]3+, [Co(phen)2(BIP)]3+ and [Co(phen)2(CIP)]3+. Journal of Coordination Chemistry. 2010, 1570-1581, IF: 2.012
【34】 Tan L.,* Chen X., Shen J., Liang X. Synthesis, DNA Binding and Photocleavage Studies of Ru(II) Complexes of phenyl-(4,5,9,14-tetraaza-benzo[b]triphenylen-1,1-yl)-methanone. Journal of the Chemical Sciences. 2009, 397-405, IF: 1.298
【35】 Su G., Huang X., Chen X., Shen J.* DNA Binding Studies of Copper(II) Complex [Cu(phen)2(BIP)](ClO4)2. Natural Science Journal of Xiangtan University. 2009,461-468, IF: 2.344
【36】 Tan L.,* Chen X., Shen J. Synthesis, Characterization, DNA-Binding, and DNA-Photocleavage Properties of Ru(II) Complexes. Australian Journal of Chemistry. 2009, 1646-1654, IF: 1.558