中国科学院大学温州研究院

智能多功能化生物材料的诊疗应用

主要研究方向：

1、智能化纳米材料递送基因药物；

2、多种药物自组装的自我递送；

3、肿瘤微环境响应的多级靶向递送体系；

4、联合药物递送

1.基因药物递送：

2.药物联合治疗：

3.诊疗一体化生物材料：

4. 药物自我递送：

沈建良

(简历)

钱宇娜

（简历）

Joy Wolfram

(简历)

秦涛

齐晓亮

李志鹏

申亮亮

赵圣哲

刘敏超

张航

陈梦宇

曾乾坤

Joy Wolfram, Ph.D.[close]
Research Interest: Nanomedicine and Extracellular Vesicles
Email: wolfram.joy@mayo.edu
PROFESSIONAL APPOINTMENTS
8/2017-present　　 Associate Research Professor; CO-PI

　　　　　　　　　　WIBE
8/2017-present　　Affiliiate Faculty
　　　　　　　　　　Department of Biology
　　　　　　　　　　University of North Florida, Jacksonville, FL, USA
　　　　　　　　　　www.unf.edu/bio/N01393994/
3/2017-present　　Assistant Professor of Medicine/Associate Consultant
　　　　　　　　　　Wolfram Laboratory for Nanomedicine and Extracellular Vesicles
　　　　　　　　　　Department of Transplantation
　　　　　　　　　　Mayo Clinic, Jacksonville, FL, USA
　　　　　　　　　　www.mayo.edu/research/faculty/wolfram-joy-emelie-joy-v-ph-d/bio-20317915
3/2017-present　　Affiliate Faculty (Affiliate Assistant Member)
　　　　　　　　　　Department of Nanomedicine
　　　　　　　　　　Houston Methodist Research Institute, Houston, TX, USA
　　　　　　　　　　www.houstonmethodist.org/faculty/joy-wolfram

POSTDOCTORAL TRAINING & EDUCATION
2016-2017　　Postdoctoral Fellow
　　　　　　　 Department of Nanomedicine
　　　　　　　 Houston Methodist Research Institute, Houston, TX, USA
　　　　　　　 Advised by Prof. Mauro Ferrari
2012-2016　　Ph.D. in Nanoscience and Technology
　　　　　　　 University of Chinese Academy of Sciences, Beijing, China
　　　　　　　 In collaboration with the Houston Methodist Research Institute, Houston, TX, USA
　　　　　　　 Co-advised by Prof. Yuliang Zhao and Prof. Mauro Ferrari

RESEARCH SUPPORT （Recent 5 years）

40,000 USD Mayo Clinic-University of Central Florida Convergence Grant (09/27/2017–09/26/2018)

　　　　　　 (Mayo Clinic PI: Wolfram; University of Central Florida PI: Seal)

　　　　　　 Silk-extracellular vesicle-nanoparticle (SEN) patch for wound healing

　　　　　　 Mayo Clinic and University of Central Florida, USA

35,000 USD U54 CA210181 (PI: Ferrari, Subaward PI: Wolfram) (03/27/2017 – 07/31/2017)

　　　　　　 Subaward: T cell transport across the blood brain barrier

　　　　　　 National Cancer Institute, National Institutes of Health, USA

19,200 EUR　 Research Grant (PI: Wolfram)(01/01/2014 – 12/31/2014)

　　　　　　 Utilization of a yeast enzyme for cancer therapy

　　　　　　 Victoriastiftelsen, Finland

PUBLICATIONS：

【1】 Wolfram J*, Nizzero S, Liu H, Li F, Zhang G, Li Z, Shen H, Blanco E, Ferrari M*. A chloroquine-induced macrophage-preconditioning strategy for improved nanodleivery. Sci Rep, 2017: in press, DOI: 10.1038/s41598-017-14221-2. (*Corresponding authors).
【2】 Liu H, Mai J, Shen J, Wolfram J, Li Z, Zhang G, Li Y, Liu X, Mu C, Zu Y, Li X, Lokesh GL, Thiviyanathan V, Volk DE, Gorensteon D, Ferrari M, Hu Z, Shen H. A Novel DNA Aptamer for Dual Targeting of Polymorphonuclear Myeloid-derived Suppressor Cells and Tumor Cells. Theranostics, 2017: in press. 
【3】 Samuelsson E, Shen H, Blanco E, Ferrari M*, Wolfram J*. Contribution of Kupffer cells to liposome accumulation in the liver. Colloids Surf B Biointerfaces, 2017:158;356-362. (*Corresponding authors).
【4】 Khalid A, Persano S, Shen H, Zhao Y, Blanco E, Ferrari M, Wolfram J*. Strategies for improving drug delivery: Nanocarriers and microenvironmental priming. Expert Opin Drug Deliv, 2017:14(7):865-877 (*Corresponding author).
【5】 Shen J, Kim HC, Wolfram J, Mu C, Zhang W, Liu H, Xie Y, Mai J, Zhang H, Li Z, Guevara M, Mao ZW, Shen H. A liposome encapsulated ruthenium polypyridine complex as a theranostic patform for triple-negative breast cancer. Nano Letters, 2017:17(5):2913-2920.
【6】 Shen J, Liu H, Mu C, Wolfram J, Zhang W, Kim HC, Zhu G, Hu Z, Ji LN, Ferrari M, Mao ZW, Shen H. Multi-step encapsulation of chemotherapy and gene silencing agents in functionalized mesoporous silica nanoparticles. Nanoscale, 2017;9(16):5329-5341. 
【7】 Shen J#, Wolfram J#, Ferrari M, Shen H. Taking the vehicle out of drug delivery. Mater Today, 2017:20(3):95-97 (# Equal contribution).
【8】 Nizzero S, Litvinov S, Alexeev D, Economides A, De Rosa E, Wolfram J, Koumoutsakos P, Ferrari M. From modeling to in vivo tracking: a new platform for the design of delivery vectors that exploit tumor microfluidics. Cancer Res 2017;77(2 Suppl):Abstract nr B04.
【9】 Venuta A, Wolfram J, Shen H, Ferrari M. Post-nano strategies for drug delivery: Multistage porous silicon microvectors. J Mater Chem B, 2017;5(2):207-219.
【10】 Persano S, Guevara ML, Wolfram J, Blanco E, Shen H, Ferrari M, Pompa PP. Label-free isothermal amplification assay for specific and highly sensitive colorimetric miRNA detection. ACS Omega, 2016;1(3):448-455 .  
【11】 Mi Y, Wolfram J, Mu C, Liu X, Blanco E, Shen H, Ferrari M. Enzyme-responsive multistage vector for drug delivery to tumor tissue. Pharm Res, 2016;113(Pt A):92-99. 
【12】 Scott B, Shen J, Nizzero S, Boom K, Persano S, Mi Y, Liu X, Zhao Y, Blanco E, Shen H, Ferrari M*, Wolfram J*. A pyruvate decarboxylase-mediated strategy for mimicking yeast metabolism in cancer cells. Pharm Res, 2016;111:413-421. (*Corresponding authors).   
【13】 Wolfram J*, Scott B, Boom K, Shen J, Borsoi C, Suri K, Grande R, Fresta M, Celia C, Zhao Y, Shen H, Ferrari M*. Hesperetin liposomes for cancer therapy. Curr Drug Deliv 2016;13(5):711-719. (*Corresponding authors).  
【14】 Mi Y, Mu C, Wolfram J, Deng Z, Hu TY, Liu X, Blanco E, Shen H, Ferrari M. A micro/nano composite for combination treatment of melanoma lung metastasis. Adv Healthc Mater 2016;5(8):936-946.

BOOK CHAPTERS：

【1】 Borsoi C, Wolfram J, Ferrari M. Nanomedicine activities in the United States and worldwide, in Nanoscience and nanotechnology for human health, ed Mueller P, Van de Voorde M, Wiley-VCH 2016;3:21-50. 
【2】 Suri K, Wolfram J, Shen H, Ferrari M. Advances in nanotechnology based drug delivery platforms and novel drug delivery systems, in Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies, ed Singh M, Salnikova M, Elsevier, 2015;I(3):41-58.

AWARDS （Recent 5 years）：

【Travel Expenses】 Conference Fellowship (registration fee, airfare, and accommodation) (2017)
10th European and Global Conference and Exhibition for Clinical Nanomedicine & Targeted Medicine, European Foundation of Clinical Nanomedicine, Basel, Switzerland
【1,500 USD】 Junior Investigator Travel Award (2017)
 　　　　　　　2017 Sage Assembly: Mapping Open Research Ecosystems, Sage Bionetworks, Seattle, WA, USA 
【Recognition】 Best Poster Award (2017)
 　　　　　　　RNA Nanotechnology Gordon Research Seminar, Ventura, CA, USA.
【1,000 USD】 1st Place Podium Award Winner (2017)
 　　　　　　　Annual Houston Methodist Academy Postdoctoral and Trainee Association Winter Science Symposium, Houston Methodist Research Institute, Houston, TX, USA
【Recognition】 Internationally Accomplished Finn (2017)
 　　　　　　　Inspired in Finland Campaign to celebrate Finland’s 100 years of independence, Finland 
 　　　　　　　Selected as one of 12 (group includes Nobel Laureates, prominent authors, and professional athletes)
 　　　　　　　maailmallamenestyvat.fi/joy-wolfram/
【Travel expenses】 Young Investigator Scholarship (conference registration fee) (2016)
 　　　　　　　7th Mayo Clinic Angiogenesis and Tumor Microenvironment Symposium, Mayo Clinic, Jacksonville, FL, USA
【Recognition】 Amgen Scholars Ten to Watch List (2016)
 　　　　　　　Amgen, USA
 　　　　　　　Best and brightest up-and-comers in science and medicine selected from 42 countries
 　　　　　　　www.amgenscholars.com/alumni/ten-to-watch
【Recognition】 Award for Excellence in Scientific Productivity (2016)
 　　　　　　　Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA
【4,800 RMB】 Director Scholarship First Prize (2015)
 　　　　　　　National Center for Nanoscience and Technology, Beijing, China.
【Travel expenses】 Conference Fellowship (registration fee, airfare, and accommodation) (2015)
 　　　　　　　European and Global Summit for Clinical Nanomedicine and Targeted Medicine, European Foundation of Clinical Nanomedicine, Basel, Switzerland 
【Travel expenses】 Gill Scholarship (airfare and accommodation) (2015) 
 　　　　　　　Ignite Entrepreneurship Conference, The Gill Foundation of Texas, TX, USA 
【3,600 RMB】 Director Scholarship Second Prize (2014)
 　　　　　　　National Center for Nanoscience and Technology, Beijing, China
【Travel expenses】 Workshop Fellowship (airfare and accommodation) (2014)
 　　　　　　　Mini-Workshop for Nanosystems and Health Science, University Magna Græcia of Catanzaro, Catanzaro, Italy 
【Recognition】 Excellent Graduate Student Award (2014) 
 　　　　　　　University of Chinese Academy of Sciences, Beijing, China.
【Travel expenses】 Conference Fellowship (registration fee and accommodation) (2014)
 　　　　　　　The European Summit for Clinical Nanomedicine and Targeted Medicine, European Foundation of Clinical Nanomedicine, Basel, Switzerland 
【3,500 ILS】 Travel Fellowship (2014)
 　　　　　　　International School of Nanomedicine, Tel Aviv University, Tel Aviv, Israel
【1,000 GBP】 Travel Award (2013)
 　　　　　　　Amgen Foundation, USA